Anupco


ANCODOX 10

Water soluble powder

COMPOSITION

Doxycycline 100 mg – Excipients up to 1 g

PHARMACOLOGICAL PROPERTIES

Doxycycline is a broad spectrum antibiotic that principally shows a bacteriostatic action. Like the other antibiotics of the tetracycline group, doxycycline inhibits bacterial protein synthesis.

Doxycycline is active against Gram-positive and Gram-negative bacteria of the following species: Staphylococcus, Diplococcus, Listeria, Bacillus, Corynebacterium, Neisseria, Moraxella, Yersinia, Brucilla spp., Erysipelothrix, Vibrio, Haemophilus, Actinobacillus, Bordetella bronchiseptica, Pasturella, Fusobacterium, Actinomyces. It is also active against spirochetes, micoplasmas, ureaplasmas, rickettsias, chlamydia, Erlichia and some protozoa (e.g. Anaplasma).

Doxycycline is very well absorbed after its oral administration. Because of its distinct lipophilic properties, doxycycline is excellently distributed over the tissues. Concentrations in the lungs of cattle and pigs are about twice as high as those in plasma. Doxycycline for the largest part is excreted with faeces (intestinal secretion, bile), in a lesser degree with urine.

INDICATIONS

For the treatment of infections caused by doxycycline sensitive germs in poultry, pigs and calves.

CONTRA-INDICATIONS

Do not use in animals with a previous history of hypersensitivity towards tetracyclines. Do not use in ruminant calves.

DOSAGE AND MODE OF ADMINISTRATION

100 mg ANCODOX 10 per kg b.w./ day to be administered with the food or drinking water.

Prevention Treatment
Poultry 100g in 160 litres of drinking water for 3-5 days 100g in 100 litres of drinking water for 3-5 days
Pigs 100g in 130 litres of drinking water for 5 days 100g in 100 litres of drinking water for 5 days
Calves - 1g per 10kg b.w./day for 3 days

UNDESIRABLE EFFECTS

Diarrhoea by disturbance of the normal intestine flora may occur. In severe cases, treatment should be stopped.

An acute enterotoxemia, cardiovascular disturbances and acute mortality seldom may occur in calves (particularly with overdoses).

SPECIAL PRECAUTIONS FOR USE AND WARNINGS

Tetracyclines primarily are bacteriostatic drugs. Simultaneous use with bactericidal antibiotics (penicillins, cephalosporins, trimethoprim) possibly may cause an antagonistic effect.

It is advised to control regularly the in vitro sensitivity of isolated pathogenic germs.

Drinking water facilities (tank, pipe, nipples, etc) should be cleaned thoroughly afetr cessation of medication.

PACK SIZE

100g, 1 kg.

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