Anupco


ANCOMIDIUM

Powder for injection

COMPOSITION

Isometamidium chloride HCl 125 mg

Excipients up to 245g

PHARMACOLOGICAL PROPERTIES

Isometamidium is a phenanthridinium compound, with antitrypanosomal activity. The primary mechanism of action is the blockade of nucleic acid synthesis. Following intramuscular administration, isometamidium is absorbed at a very slow rate and over a prolonged period, such that high amounts of the drug are found at the injection site even after 6 weeks. This is attributed to its strong binding to tissue macromolecules and its ability to precipitate tissue proteins resulting in inflammation and coagulative necrosis at the injection site.

INDICATIONS

Prevention and treatment of trypanosomiasis caused by Trypanosoma vivax, T. congolense, T. brucei and T. evansi in cattle, sheep, goats, horses, dogs, camels and dromedaries. Preventative dosage ensures protection for 2-4 months. When clinical cases occur the whole group should be treated.

CONTRA-INDICATIONS

Hypersensitivity to the actute substance or to any of the excipients. Subcutaneous injection is contra-indicated.

DOSAGE AND MODE OF ADMINISTRATION

Preparation of the solution for injection:

Dissolve the content of one sachet of ANCOMIDIUM in 6ml of sterile water for injection to prepare a 2% solution.

Dissolve the content of a sachet in 12ml of water for injection to prepare a 1% solution.

Boiled and cooled as well as distilled water may be used when sterile water for injection is not avilable. Once dissolved, the solution is to be used immediately. It can be stored cool (below 15 degrees centigrade) in waterproof containers for 24-48 hours.

Mode of administration:

Deep intramuscular injection, preferably in the middle third of the neck in large amimals. If more than 10ml is to be injected, the total volume should be divided over two injection sites, one on each side of the neck. Avoid accidental subcutaneous injection. Be sure that the syringe is completely empty before retracting it from the intramuscular injection site. Apply firm pressure on the injection site to prevent leaking. Sheep and goats are injected deep in the muscles of the thigh. Camels are injected VERY SLOWLY intravenously.

Dosage:

Cattle, sheep, goats: Treatment: 0.25-0.5mg/kg I.M. Prevention: 0.5-1mg/kg I.M.

Camels, dromedaries: 0.5-0.75mg/kg I.M. as a 0.25-1% solution slowly by I.V.

Horses: 0.5mg/kg by deep I.M. injection

Dogs: 1mg/kg I.M.

Body weight Dosage for the 2% solution
(kg) 0.25 mg/kg 0.50 mg/kg 0.75 mg/kg 1 mg/kg
50 1.25ml 2.50ml
100 1.25ml 2.50ml 3.75ml 5.00ml
150 3.75ml 7.50ml
200 2.50ml 5.00ml 7.50ml 10.00ml
250 6.25ml 12.50ml
300 3.75ml 7.50ml 11.25ml 15.00ml
350 8.75ml 17.50ml
400 5.00ml 10.00ml 15.00ml 20.00ml
450 11.25ml 22.50ml
500 6.25ml 12.50ml 18.75ml 25.00ml

One sachet is sufficient for the preventative treatment of 1 animal or the curative treatment of 2 animals, weighing 250kg each.

Frequency of preventative treatment:

Repeated injections are needed at intervals of 10 to 12 weeks or more depending on the level of fly challenge.

UNDESIRABLE EFFECTS

Local irritation at the injectionásite may occur. Therefore deep IM injection is required.

SPECIAL PRECAUTIONS AND WARNINGS

Avoid leakage of the product into the subcutaneous tissues.

If more than 10ml is to be injected, the total volume should be divided over two injection sites.

Individual sensitivity to the product is possible.

PACK SIZE

Box with 10 sachets.

Please be aware that product specifications and availability can differ between countries. For detailed information in this regard, please contact us.

You are viewing the English version of this website enesfr