Solution for injection


Phenylbutazone 200 mg

Excipients up to 1 ml


Phenylbutazone is a synthetic pyrazolon derivate with anti-inflammatory, analgesic and antipyretic activities (NSAID). A considerable part of its activity can be ascribed to itsm metabolite oxyphenbutazone. The antiphlogistic action results from the inhibition of prostaglandin sythesis, which also play a part as pain mediators.


ANCOPHEN can be used for the control of inflammation, subsequent tissue damage and associated pain. ANCOPHEN is especially of value of acute inflammatory conditions associated with the musculo-skeletal system and lameness.

Horses: arthritic conditions, tenosynovitis, tendinitis, bursitis, muscular strains, laminitis, soft tissue reactions and pain e.g. associated with wounds, fractures, lymphangitis, bruisings etc.

Cattle: arthritic conditions and soft tissue reactions.

Dogs: arthritis, posterior paralysis, luxation, myositis and pain e.g. associated with injuries and fractures.

Chronic arthritic conditions, often associated with reactions of bony structures, usually will respond to phenylbutazone therapy, but often only a temporary improvement is obtained with recurrence of clinical sypmtoms after discontinuance of treatment.


Disturbances of the heart, liver and kidneys, gastro-intestinal lesions, dehydration, severe blood dyscrasia, hypersensitivity.

Other contra-indications are extra-vascular injection (flebitis) and overload of the locomotory system after disappearance of the clinical symptoms during therapy, with an increased risk of aggravation of the disorder.

Do not administer in racing horses and in foals younger than 3 months.


Horse: only by slow and strict I.V. injection: 1 ml/ 50kg b.w. once daily for max. 4 days.

Cattle: initial dose: 1 ml/ 25kg b.w. once daily I.V. or by deep I.M. injection for max 5 days. Maintenance dose: 1 ml/ 60 kg b.w.

Young calves: 1 ml/ 50 with 2-day intervals

Dogs: only by slow and strict I.V. injection: 1 ml/ 16kg b.w. every 12 hours for max. 2 days.


At recommended dosage and duration of treatment it is unlikely that undesirable effects will occur.

Daily administration of the recommended dosage (4.4 mg/ kg b.w.) during more than five days in horses, can cause loss of appetite, depression and change of certain blood parameters.

Especially with long-term therapy, possible side effects in bovines (leucopenia, liver and kidney necrosis, irritation of the gastro-intestinal mucosa), particularly in young calves, cannot be excluded.

Extra-vascular injection can acuse swelling, inflammation and lesions of the veins (eventually thrombosis).

An accidental intra-arterial injection causes excitation, exhaustion and sometimes death.


Beacuse of the rather narrow safety margin, especially in horses, very young or very old animals, the recommended dosage has to be followed strictly. Do not exceed the recommended maximal duration of treatment.

The intravenous injection has to be executed carefully and slowly. In order to avoid an accidental extra-vascular injection it is advised to control first if the syringe is really intravenous by aspiration of a little bit of blood.

Always apply sufficient amounts of drinking water to the animals under treatment. In case of inflammations accompanied by infections, an adapted antimicrobial treatment has to be initiated.


100 ml vials.

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