Anupco


ANCOTRYP

COMPOSITION

Diminazene diaceturateááááááááááááááááááááááááááááááááá 1.05 g

Antipyrineáááááááááááááááááááááááááááááááááááááááááááááááááááááááááá 1.31 g / sachet

 

PHARMACOLOGICAL PROPERTIES

Diminazene diaceturate is an antiprotozoal substance active against the following babesiosis (piroplasmosis) causing agents: Babesia bigemina, B. divergens, B. bovis in cattle; B. caballi and B. equi in horses; B. ovis in sheep; B. canis and B. gibsoni in dogs and Theileria annulata in cattle.

It is highly effective against Trypanosoma congolense and T. vivax and moderately active against T. bruce´, T. evansi and T. equiperdum.

Resistance against diminazene diaceturate only seldom was reported.

Antipyrine (phenazone) reduces fever especially in case of babesiosis.

 

TARGET SPECIES

Cattle, camel, horse, sheep, goat, dog.

 

INDICATIONS

For the treatment of babesiosis and theileriasis in animals. For the sterilisation of babesia infections in ruminants and horses to be exported or moved to disease free areas.

For the treatment of canine malignant icterus.

For the treatment and prevention of trypanosomiasis in animals.

 

CONTRA-INDICATIONS

None.

 

DOSAGE AND MODE OF ADMINISTRATION

Dissolve 1 sachet of 2.36 g powder in 15 ml (or 1 sachet of 23.6 g in 150 ml) of sterile water for injection to obtain a ready-to-use 7 % diminazene diaceturate solution.

Inject the solution by subcutaneous or intramuscular routes. Use preferably the I.M. route in horses.

 

Treatment of babesiosis:

Cattle, sheep, dog: 3.5 mg diminazene diaceturate/kg bw or 1 ml/20 kg bw

Horse: 5 mg diminazene diaceturate/kg bw or ▒10 ml/140 kg bw on 2 consecutive days.

 

Treatment of theileriasis:

Cattle: 5-10 mg diminazene diaceturate/kg bw or 10 ml/70-140 kg bw for 2 consecutive days or 3-4 injections on alternate days.

 

Treatment of trypanosomiasis:

Cattle, horse, dog:

T. congolense, T. vivax: 3.5 mg diminazene diaceturate/kg bw or 1 ml/20 kg bw

T.brucei, T.evansi, T.equiperdum: 7 mg diminazene diaceturate/kg bw or 1 ml/10 kg bw

Camels: 1.75 mg (max. 3.5 mg) diminazene diaceturate/kg bw or 1 ml (max. 2 ml)/40 kg bw

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UNDESIRABLE EFFECTS

Transient local reactions may appear at the injection site.

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SPECIAL PRECAUTIONS FOR USE AND WARNINGS

For accurate dosing, accurate estimates or determinations of animal weights are essential.

Where volume to be injected exceeds 20ml, administer in two injection sites.

Dogs and camels are very sensitive to diminazene toxicity. Overdoses or multiple doses may cause severe nervous disturbances and hepatotoxic reactions. It is advised to use lower dosage rates in these species.

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PACK SIZE

10 sachets of 2.36g.

 

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