Anupco


GENTAMYCIN 100

Solution for injection

COMPOSITION

Gentamicin sulphate equivalent to 100 mg base

Excipients up to 1 ml

PHARMACOLOGICAL PROPERTIES

Gentamicin is a broad-spectrum aminoglycoside antibiotic with activity against Gram-positive (eg. Staphylococci, Streptococci, Corynebacterium spp.) and Gram-negative bacteria. In contrast with most other currently used antibiotics, gentamicin exerts pronounced bactericidal activity against several, often multi-resistant, Gram-negative pathogens, such as E. Coli, Salmonella spp., Klebsiella spp., Proteus spp. and Pseudomonas spp.

INDICATIONS

For the treatment of infectious diseases, caused by Gram-positive and Gram-negative bacteria susceptible to gentamicin, such as: respiratory tract infections, gastro- intestinal infections (colibacillosis, salmonellosis), uro-genital tract infections, skin and wound infections, speticaemia, arthritis.

CONTRA-INDICATIONS

Do not use in known cases of renal impairment.

Do not use in known cases of sensitivity to gentamicin.

Do not use in pregnant animals.

Overdosing may result in neuromuscular block, specially after intravenous administration and in anaesthetised animals.

Use in anaesthetised animals is contra-indicated.

DOSAGE AND MODE OF ADMINISTRATION

Cattle, horses, sheep: 2-4 mg/kg bodyweight twiceádaily (=2-4 ml/100 kg bodyweight)

Pigs: 2-4 mg/kg bodyweight twiceádaily (=1-2 ml/50 kg bodyweight)

Poultry: 5-10 mg/kg bodyweight

UNDESIRABLE EFFECTS

Nephrotoxic and vestibulotoxic (ataxia) signs may occur, especially after use of large doses and long term treatments. At recommended doses these side effects very seldom occur. Antidote in case of neuromuscular block (curare-like paralysis): calcium infusion or neostigmine.

SPECIAL PRECAUTIONS FOR USE AND WARNINGS

Treatment should not exceed 5 days with biochemical confirmation of normal renal function.

A longer dosing interval should be considered immediately prior to anaesthesia since halothane significantly increases the half-life of gentamicin.

PACK SIZE

100 ml multidose vials.

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