GENTAMYCIN 50

Solution for injection

COMPOSITION

Gentamicin sulphate equivalent to 50 mg base

Excipients up to 1 ml

PHARMACOLOGICAL PROPERTIES

Gentamicin is a broad-spectrum aminoglycoside antibiotic with activity against Gram-postive (eg. Staphylococci, Streptococci, Corynebacterium spp.) and Gram-negative bacteria. In contrast with most other currently used antibiotics, gentamicin exerts pronounced bactericidal activity against several, often multi-resistant, Gram-negative pathogens, such as E. Coli, Salmonella spp., Klebsiella spp., Proteus spp. and Pseudomonas spp.

INDICATIONS

For treatment of infectious diseases, caused by Gram-positive and Gram-negative bacteria susceptible to gentamicin, such as: respiratory tract infections, gastric and intestinal infections (colibacillosis, salmonellosis), uro-genital tract infections, skin and wound infections, septicaemia, arthritis, omphalitis, otitis and tonsillitis in dogs.

CONTRA-INDICATIONS

Overdosing may result in neuromuscular block, especially after intravenous administration and in anaesthetised animals. Use in anaesthetised animals is contra-indicated.

DOSAGE AND MODE OF ADMINISTRATION

By intramuscular, subcutaneous or slow intravenous injection.

Cattle, pigs: 2-4 mg Gentamicin/ kg b.w. (4-8 ml Gentamycin 50) once or twice daily.

Dogs, cats: 1 ml/ 10kg b.w. once or twice daily

By intrauterine infusion (mares): 25-50 ml + 250-500ml of physiological saline solution.

UNDESIRABLE EFFECTS

Nephrotoxic and vestibulotoxic (ataxia) signs may occur, especially after use of large doses and long term treatments. At recommended doses these side effects very seldom occur. Antidote in case of neuromuscular block (curare-like paralysis): calcium infusion or neostigmine.

SPECIAL PRECAUTIONS FOR USE AND WARNINGS

Care should be taken, however, in case of an existing renal disturbance and in post-partum cows, especially those with a history of milk-fever.

PACK SIZE

50 ml, 100 ml vials

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