Anupco


IVERMECTIN 10

Solution for injection

COMPOSITION

Ivermectin 10 mg/ml (1% w/v)

PHARMACOLOGICAL PROPERTIES

Ivermectin belongs to the family of avermectins, endectocides of the class of macrocyclic lactones.

Ivermectin acts in two ways, by interference with neural transmission and the opening of chloride ion channels. Ivermectin increases the release of gamma amino butyric acid (GABA) closeáto the post-synaptic receptors inducing the opening of the cloride ion channels and decrease in cellular function. There is also evidence of ivermectin acting directly and independant from GABA. The opening of the pre-synaptic chloride ion channels is followed by an efflux of chloride ions and a depolarization of the terminal nerve. These effects interfere with normal neurotransmission between nerves and muscles resulting in paralysis and eventually death.

INDICATIONS

Cattle and camels:

For the treatment and control of gastro-intestinal nematodes, lungworms, eyeworms, warbles,ámites and lice (as shown below) of beef and non-lactating dairy cattle.

Gastro-intestinal worms: (adult and fourth stage larvae): Ostertagia ostertagi (including inhibited larval stages), Ostertagia lyrata, Haemonchus placei, Trichostrongylus axei, Trichostrongylus colubriformis, Cooperia oncophora, Cooperia punctata, Cooperia pectinata, Bunostomum phlebotomum, Oesophagostomum radiatum, Strongyloides papillosis (adult), Nematodirus helvetianus (adult), Nematodirus spathiger (adult) and Trichus spp (adult).

Lungworms: (adult and fourth stage larvae): Dictyocaulus viviparus

Eyeworms: (adult): Thelazia spp

Warbles: (parasitic stages): Hypoderma bovis and H. lineatum

Mites: Psoroptes bovis, Sarcoptes scabiei var. bovis

Sucking lice: Linognathus vituli, Haematopinus eurysternus and Solenopotes capillatus

May also be used as an aid in the control of the mange mite Chorioptes bovis and biting lice (Damalinia bovis), but complete elimination may not occur.

Pigs:

For the treatment and control of gastro-intestinal nematodes, lungworms, lice and mange mites in pigs. Ivermectin 10 Injection at the recommended dose of 300mcg ivermectin per kg bodyweight provides effective control against the following parasites of pigs:

Gastro-intestinal worms: (adult and fourth stage larvae): Ascaris suum, Hyostrongylus rubidus, Oesophagostomum spp. and adult and somatic stages of Strongyloides ransomi.

Lungworms: Metastrongylus spp (adult)

Lice: Haematopinus suis

Mites: Sarcoptes scabiei var. suis

Sheep:

For the treatment and control of psoroptic mange (sheep scab), gastro-intestinal nematodes, lungworms and nasal bots of sheep.

Gastro-intestinal worms: (adult and fourth stage larvae): Ostertagia circumcinta, O. trifurcata, Haemonchus contortus, Trichostrongylus axei (adults), T. Colubriformis and T. vitrinus (adults), Cooperia curticei, Oesophagostomum coulmbianum, O. venulosum, Nematodirus filicollis, Chabertia ovina, Trichus ovis (adults). Inhibited larval stages and benzimidazole resistant strains of Haemonchus contortus and Ostertagia circumcincta are also controlled.

Lungworm: Dictyocaulus filaria (adults and fourth stage larvae), Protostrongylus rufescens (adults).

Mange mites: Psoroptes ovis

Nasal bot: Oestrus ovis (all larval stages)

CONTRA-INDICATIONS

IVERMECTIN 10 injection should not be used in other species as severe adverse reactions, including fatalities, may occur.

DOSAGE AND MODE OF ADMINISTRATION

Cattle and camels: 1 ml per 50 kg bodyweight (based on a recommended dosage level of 200mcg ivermectin per kg bodyweight), administered by subcutaneous injection in front of or behind the shoulder using asceptic technique. A sterile 17 gauge x half inch (15-20 mm)áneedle is recommended.

Pigs: 1 ml per 33 kg bodyweight (based on a recommended dosage level of 300 mcg ivermectin per kg bodyweight), administered by subcutaneous injection in front of or behind the shoulder using asceptic technique. A sterile 17 gauge x half inch (15-20 mm) needle is recommended.

Sheep: 0.50 ml per 25 kg bodyweight (based on recommmended level of 200 mcg ivermectin per kg bodyweight). Inject subcutaneously into the neck using asceptic technique, a sterile 17 gauge x half inch (15-20 mm) needleáis recommended.

UNDESIRABLE EFFECTS

Transitory discomfort has been observed in some cattle follwoing subcutaneous administration. A low incidence of soft tissue swelling at the injection site has been observed. These reactions have disappeared without treatment. Immediately following subcutaneous injcetion, activity suggesting pain, sometimes intense, but usually transient, has been observed in some sheep.

SPECIAL PRECAUTIONS FOR USE AND WARNINGS

This product is not for intraveous or intramuscular use.

Ivermectin 10 should not be used in other species as severe adverse reactions, including fatalities in dogs, may occur.

Do not mix with other medicinal products.

Store below 25░C and protect from light.

Keep out of the reach of children.

PACK SIZE

10ml, 20ml, 50ml, 100ml and 500ml multi dose vials.

Please be aware that product specifications and availability can differ between countries. For detailed information in this regard, please contact us.

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