Solution for injection


Oxytocin 10 I.U.- Phenol- Citric acid monohydrate (E330)- Sodium chloride- Water for injection up to 1 ml.


Oxytocin directly stimulates contractions of smooth musculature of the uterus and the mammary gland. The mechanism of this stimulating action implies mediation by oxytocin receptors, and initiation of contractions by influx of calcium ions in smooth muscle cells. Oxytocin stimulates both the frequency and force of uterine contractions with a maximum response at parturition and a gradual decrease in the puerperal phase. Uterine responsiveness to oxytocin is higher during oestrus than during dioestrus and anoestrus. Oxytocin stimulates contraction of the myoepithelial cells of alveoli and small milk ducts in the mammary gland, in this way stimulating milk let-down into the large ducts and increasing total milk yield by making the residual milk available for milking. Magnitude and onset of this action are related to dose and route of administration.

Oxytocin is rapidly absorbed after intramuscular and subcutaneous injection (effects within few minutes). It circulates in blood mostly as its free form, partly loosely bound to carrier proteins. Itáis widely distributed into various tissues with a certain affinity for kidneys, liver, hypophysis, uterus and mammary gland. After a large increase after injection, oxytocin blood levels rapidly decline and oxytocin is rapidly degraded in various tissues into smaller peptides and amino acids.


To stimulate uterine contractions:

- During parturition: partus induction in mares, uterine inertia in sows, bitches and queens.

- During the early puerperium: to promote uterine involution (uterine atonia, after reposition of uterine prolapse, aid in the removal of retained placenta, for the reduction of retained placenta in cows).

- During oestrus: aid in the treatment of endometritis (for removal of intrauterine fluid) in mares.

To promote milk let-down (post-partum agalactia in heifers, maiden mares and as an adjunctive treatment of MMA in sows) and for the removal of residual milk (supportive therapy in case of mastitis).


Do not use at parturition when the cervix is not relaxed or in case of dystocia due to abnormal presentation of foetus until correction is accomplished, malformation of the foetus, oversized foetus or other abnormalities of foetal and maternal origin that complicates a normal passage through the birth channel.


Stimulation of uterine contractions:

- Mares: I.M.: 50 I.U. or 5 ml of Oxytocin/ animal (500 kg b.w.). I.V.:10-20 I.U. or 1-2 ml of Oxytocin/ animal (500 kg b.w.). Partus induction: delivery is usually accomplished within 15-90 minutes.

For the removal of intrauterine fluid (endometritis): administer 20 I.U. or 2 ml of Oxytocin per animal (500 kg b.w.) by I.V. injection in association with oestrus, mating or insemination (before expected ovulation).

- Cows, heifers: I.M.: 30-60 I.U. or 3-6 ml of Oxytocin/ animal (500 kg b.w.)

- Ewes, goats: I.M.: 10 I.U. or 1 ml of Oxytocin/áanimal (50 kg b.w.)

Post-partum use in cows, ewes and goats: since the responsiveness of the uterus rapidly declines after delivery, injections should be given within 24 hours after delivery. For the reduction of the incidence of retained placenta in cows, injections should be given within 6 hours of calving.

- Sows: I.M.: 10- 20 I.U. or 1-2 ml of Oxytocin/ animal ( 200 kg b.w.). I.V.: 5 I.U. or 0.5 ml of Oxytocin/ animal (200 kg b.w)

- Bitches, queens: I.M., S.C., I.V.: 0.5 to 1 I.U./ kg b.w. with a maximum of 20 I.U./ animal in bitches and 5 I.U./animal in queens.

Injections should not be repeated sooner than 30 minutes after I.V. injection and not sooner than 1 hour after I.M. or S.C. injection.

Induction of milk let-down/ removal of residual milk:

- Mares: I.M.: 20 I.U. or 2 ml of Oxytocin/ animal (500 kg b.w.). I.V.: 10 I.U. or 1 ml of Oxytocin/ animal (500 kg b.w.)

- Cows, heifers: I.M.: 20 I.U. or 2 ml of Oxytocin/ animal (500 kg b.w.). I.V.: 10 I.U. or 1 ml Oxytocin/ animal (500 kg b.w.)

To be given immediately after milking. For the removal of residual milk intramuscular injection should be followed by stripping (milking out) 2 to 3 minutes later.

- Ewes, goats: I.M.: 10 I.U. or 1 ml of Oxytocin/ animal (50 kg b.w.)

- Sows: I.M.: 10-20 I.U. or 1-2 ml of Oxytocin/ animal (200 kg b.w.). I.V.: 5 I.U. or 0.5 ml of Oxytocin/ animal (200kg b.w.)


When used appropriately at recommended dosages, oxytocin rarely causes significant adverse reactions. Oxytocin given during the early stage of oestrus may cause a decrease of the oestrus cycle length in ruminants and sows (luteolytic effect).


For prepartum use always control the degree of relaxation of the cervix and the position of the foetus. Full relaxation of the cervix should be accomplished either naturally or by the administration of oestrogens prior to oxytocin therapy. The position of the foetus should be corrected prior to oxytocin administration if necessary.

Parturition should only be induced in mares that show readiness to birth (udder development + colostrum drops, softened cervix, relaxed pelvic ligaments, gestation length> 230- 330 days,…).

Too high doses or too frequent administrations at parturition may cause prolonged spastic contractions of the uterus leading to tumultuous labour and more discomfort to the mother animal, a delay to the birth, increased frequency of dystocia with increased danger for maternal (e.g. uterine rupture) and foetal damage.

To avoid possible incompatibilities, oxytocin should not be mixed with other drugs for simultaneous injection.


50 ml, 100 ml vials

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