Anupco


TYLOSIN 200

Solution for Injection

COMPOSITION

Tylosin base (as tartrate) 200 mg/ ml

PHARMACOLOGICAL PROPERTIES

Tylosin is a macrolide antibiotic, mainly active against Gram-positive bacteria and mycoplasmas. It is also active against some Gram-negative bacteria, spriochetes, some rickettsia and chlamydia. At commonly recommended doses, tylosin acts bacteriostatically. It inhibits protein synthesis of susceptible micro-organisms by binding to subunits of the 50-S ribosome and by inhibition of the translocation step.

Chromosomal mutation to resistance may develop rather fast for tylosin, although such resistance is relatively unstable. Extra-chromosomal plasmide mediated resistance against macrolide antibiotics also occurs.

After intramuscular injection, tylosin tartrate is well absorbed from the injection site. A maximum plasma level is attained after about 3 hours. Tylosin is an organic base that is moderately bound by serum proteins (30-40%) and possesses a high degree of lipid solubility. Therefore, it is well distributed through the body, with concentrations in tissues and biological fluids exceeding several times the plasma levels. Tylosin is extensively metabolized in the liver and excreted with bile and urine.

INDICATIONS

TYLOSIN 200 can be used for treatment and prophylaxis of the following infections:

Poultry: Mycoplasma infections (Chronic Respiratory Disease, infectious sinusitis).

Dogs, cats: Infections of the skin, respiratory-, urogenital- and gastro-intestinal tract, tonsillitis, otitis externa, infections of the circumanal glands, wound infections and secondary bacterial infections in case of viral infections such as distemper and panleucopenia.

Cattle, camels: Mycoplasma infections, respiratory tract infections, metritis, foot rot.

Sheep, goats: Mycoplasma infections.

Pigs: Pig dysentery, polyserositis, enzootic pneumonia, rhinitis atrophicans and exudative epidermitis, arthritis and erysipelas.

Horses: Respiratory infections, strangles.

CONTRA-INDICATIONS

Hypersensitivity for tylosin.

DOSAGE AND MODE OF ADMINISTRATION

By intramuscular injection, or subcutaneous injection for dogs and cats.

Cattle, camels, sheep and goats: 2-5 ml TYLOSIN 200 per 100 kg body weight (equivalent to 4-10 mg Tylosin/ kg)

Pigs: 1-5 ml TYLOSIN 200 perá100 kg body weight (equivalent to 2-10 mg Tylosin/ kg)

Dogs and cats: 0.10-0.50 ml TYLOSIN 200 per 10 kg body weight (equivalent to 2-10 mg Tylosin/ kg)

Repeat treatment at 12 hourly intervals if necessary.

ADVERSE REACTIONS

Temporary swelling at the injection site.

SPECIAL PRECAUTIONS AND WARNINGS

For repeated use, change injection site.

Irritation and pain at injection site may be observed occasionally.

PACK SIZE

100 ml multi dose vials.

Please be aware that product specifications and availability can differ between countries. For detailed information in this regard, please contact us.

 

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